Phenobarbital does not worsen outcomes of neonatal hypoxia on hippocampal LTP on rats.

ABSTRACT:

Introduction

Neonatal hypoxia is a common cause of early-life seizures. Both hypoxia-induced seizures (HS), and the drugs used to treat them (e.g., phenobarbital, PB), have been reported to have long-lasting impacts on brain development. For example, in neonatal rodents, HS reduces hippocampal long-term potentiation (LTP), while PB exposure disrupts GABAergic synaptic maturation in the hippocampus. Prior studies have examined the impact of HS and drug treatment separately, but in the clinic, PB is unlikely to be given to neonates without seizures, and neonates with seizures are very likely to receive PB. To address this gap, we assessed the combined and separate impacts of neonatal HS and PB treatment on the development of hippocampal LTP.

Methods

Male and female postnatal d

SUBMITTER: Sanchez-Brualla I 

PROVIDER: S-EPMC10703306 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature