Postsynaptic mitochondria are positioned to support functional diversity of dendritic spines.

ABSTRACT: Postsynaptic mitochondria are critical for the development, plasticity, and maintenance of synaptic inputs. However, their relationship to synaptic structure and functional activity is unknown. We examined a correlative dataset from ferret visual cortex with in vivo two-photon calcium imaging of dendritic spines during visual stimulation and electron microscopy reconstructions of spine ultrastructure, investigating mitochondrial abundance near functionally and structurally characterized spines. Surprisingly, we found no correlation to structural measures of synaptic strength. Instead, we found that mitochondria are positioned near spines with orientation preferences that are dissimilar to the somatic preference. Additionally, we found that mitochondria are positioned near groups of spines

SUBMITTER: Thomas CI 

PROVIDER: S-EPMC10703439 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature