Adoptive transfer of allergen-expressing B cells prevents IgE-mediated allergy.

ABSTRACT:

Introduction

Prophylactic strategies to prevent the development of allergies by establishing tolerance remain an unmet medical need. We previously reported that the transfer of autologous hematopoietic stem cells (HSC) expressing the major timothy grass pollen allergen, Phl p 5, on their cell surface induced allergen-specific tolerance in mice. In this study, we investigated the ability of allergen-expressing immune cells (dendritic cells, CD4⁺ T cells, CD8⁺ T cells, and CD19⁺ B cells) to induce allergen-specific tolerance in naive mice and identified CD19⁺ B cells as promising candidates for allergen-specific cell therapy.

Methods

For this purpose, CD19⁺ B cells were isolated from Phl p 5-transgenic BALB/c mice and tran

SUBMITTER: Prickler L 

PROVIDER: S-EPMC10703460 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature