Exploring the role of copine 1 in human colorectal cancer: investigating its association with tumorigenesis and metastasis.

ABSTRACT:

Purpose

This study aimed to investigate the potential role of copine-1 (CPNE1), a calcium-dependent membrane-binding protein encoded by the CPNE1 gene, in colorectal cancer (CRC). Despite previous research on the involvement of copine family members in various solid tumors, the specific role of CPNE1 in CRC remains poorly understood.

Methods

We conducted clinicopathological analysis and functional studies to explore the impact of CPNE1 in human CRC. We examined the expression levels of CPNE1 in CRC patients and correlated it with invasive depth, lymph node metastasis, distant metastasis, lymphatic invasion, and TNM stage. Additionally, we performed experiments to assess the functional consequences of CPNE1 knockdown in CRC cells, including proliferation, colony format

SUBMITTER: Lee JK 

PROVIDER: S-EPMC10703583 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature