IQGAP3 is relevant to prostate cancer: A detailed presentation of potential pathomechanisms.

ABSTRACT:

Introduction

IQGAP3 possesses oncogenic actions; its impact on prostate cancer (PC) remains unclear.

Objective

We will investigate IQGAP3's association with PC progression, key mechanisms, prognosis, and immune evasion.

Methods

IQGAP3 expression in PC was examined by immunohistochemistry and using multiple datasets. IQGAP3 network was analyzed for pathway alterations and used to construct a multigene signature (SigIQGAP3NW). SigIQGAP3NW was characterized using LNCaP cell-derived castration-resistant PCs (CRPCs), analyzed for prognostic value in 26 human cancer types, and studied for association with immune evasion.

Results

Increases in IQGAP3 expression associated with PC tumorigenesis, tumor grade, metastasis, and p53 mutation. IQGAP3 correlative genes were do

SUBMITTER: Mei W 

PROVIDER: S-EPMC10703617 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature