Targeting DNA methylation and demethylation in diabetic foot ulcers.

ABSTRACT:

Background

Poor wound healing is a significant complication of diabetes, which is commonly caused by neuropathy, trauma, deformities, plantar hypertension and peripheral arterial disease. Diabetic foot ulcers (DFU) are difficult to heal, which makes patients susceptible to infections and can ultimately conduce to limb amputation or even death in severe cases. An increasing number of studies have found that epigenetic alterations are strongly associated with poor wound healing in diabetes.

Aim of review

This work provides significant insights into the development of therapeutics for improving chronic diabetic wound healing, particularly by targeting and regulating DNA methylation and demethylation in DFU. Key scientific concepts of review: DNA methylation and demethylation pl

SUBMITTER: Deng JY 

PROVIDER: S-EPMC10703625 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature