Knockdown of FOXRED2 restrains proliferation, invasion and migration of human melanoma cells.

ABSTRACT:

Objectives

This experiment investigated the role of the FAD-dependent oxidoreductase domain-containing 2 (FOXRED2) in the development of cutaneous malignant melanoma.

Methods

We explored the expression and prognostic effects of FOXRED2 in cutaneous malignant melanoma by performing bioinformatics analyses and immunohistochemical staining experiments and verified the biological influence of FOXRED2 on human melanoma cells using in vitro experiments.

Results

FOXRED2 expression was significantly higher in cutaneous malignant melanoma compared to normal skin and nevus tissues and closely associated with prognosis. The expression levels of FOXRED2 mRNA and protein were significantly upregulated in human melanoma cell lines, and knocking down FOXRED2 expression inhibits prol

SUBMITTER: Li M 

PROVIDER: S-EPMC10703634 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature