North and East African mitochondrial genetic variation needs further characterization towards precision medicine.

ABSTRACT:

Introduction

Mitochondria are maternally inherited cell organelles with their own genome, and perform various functions in eukaryotic cells such as energy production and cellular homeostasis. Due to their inheritance and manifold biological roles in health and disease, mitochondrial genetics serves a dual purpose of tracing the history as well as disease susceptibility of human populations across the globe. This work requires a comprehensive catalogue of commonly observed genetic variations in the mitochondrial DNAs for all regions throughout the world. So far, however, certain regions, such as North and East Africa have been understudied.

Objectives

To address this shortcoming, we have created the most comprehensive quality-controlled North and East African mitochondrial da

SUBMITTER: Fahnrich A 

PROVIDER: S-EPMC10703728 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature