A review of biological targets and therapeutic approaches in the management of triple-negative breast cancer.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is a heterogeneous, aggressive phenotype of breast cancer with associated chemoresistance. The development of chemo- or radioresistance could be attributed to diverse tumor microenvironments, overexpression of membrane proteins (transporters), epigenetic changes, and alteration of the cell signaling pathways/genes associated with the development of cancer stem cells (CSCs).

Aim of review

Due to the diverse and heterogeneous nature of TNBC, therapeutic response to the existing modalities offers limited scope and thus results in reccurance after therapy. To establish landmark therapeutic efficacy, a number of novel therapeutic modalities have been proposed. In addition, reversal of the resistance that developed during treatment m

SUBMITTER: Kumar H 

PROVIDER: S-EPMC10703733 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature