Modifiable risk factors for subsequent lethal prostate cancer among men with an initially negative prostate biopsy.

ABSTRACT:

Background

Previously suggested modifiable risk factors for prostate cancer could have resulted from detection bias because diagnosis requires a biopsy. We investigated modifiable risk factors for a subsequent cancer diagnosis among men with an initially negative prostate biopsy.

Methods

In total, 10,396 participants of the Health Professionals Follow-up Study with an initial negative prostate biopsy after 1994 were followed for incident prostate cancer until 2017. Potential risk factors were based on previous studies in the general population. Outcomes included localised, advanced, and lethal prostate cancer.

Results

With 1851 prostate cancer cases (168 lethal) diagnosed over 23 years of follow-up, the 20-year risk of any prostate cancer diagnosis was 18.5% (95% CI:

SUBMITTER: Feng X 

PROVIDER: S-EPMC10703766 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature