Safety and antimalarial therapeutic index of alkaloid-rich extract of Phyllanthus amarus Schumach. & Thonn. in mice.

ABSTRACT:

Background

Malaria fever is known to cause around one million passings per annum. This life-threatening infection is predominant in most part of Africa. Malaria vaccinations are challenging in Nigeria, particularly in rural areas. Drugs derived from plants have been utilized customarily to treat malaria. In this manner, assurance of the harmfulness and antimalarial capacity of plant derived drugs can demonstrate to be the source of novel lead compound to control malaria. The aim of this study was to evaluate the safety and antimalarial therapeutic index of alkaloid-rich extract of Phyllanthus amarus in mice.

Methods

Thirty rats (n = 5/group) were used for the oral acute toxicity study and administered with varying doses (0, 100, 500, 1000, 2000 and 5000 mg/kg b.wt) of

SUBMITTER: Okom SU 

PROVIDER: S-EPMC10703837 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature