Epigenome-wide association studies of prenatal maternal mental health and infant epigenetic profiles: a systematic review.

ABSTRACT: Prenatal stress and poor maternal mental health are associated with adverse offspring outcomes; however, the biological mechanisms are unknown. Epigenetic modification has linked maternal health with offspring development. Epigenome-wide association studies (EWAS) have examined offspring DNA methylation profiles for association with prenatal maternal mental health to elucidate mechanisms of these complex relationships. The objective of this study is to provide a comprehensive, systematic review of EWASs of infant epigenetic profiles and prenatal maternal anxiety, depression, or depression treatment. We conducted a systematic literature search following PRISMA guidelines for EWAS studies between prenatal maternal mental health and infant epigenetics through May 22, 2023. Of 645 identified a

SUBMITTER: Drzymalla E 

PROVIDER: S-EPMC10703876 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature