Hypertension linked to Alzheimer's disease via stroke: Mendelian randomization.

ABSTRACT: This study aimed to investigate the relationship between hypertension and Alzheimer's disease (AD) and demonstrate the key role of stroke in this relationship using mediating Mendelian randomization. AD, a neurodegenerative disease characterized by memory loss, cognitive impairment, and behavioral abnormalities, severely affects the quality of life of patients. Hypertension is an important risk factor for AD. However, the precise mechanism underlying this relationship is unclear. To investigate the relationship between hypertension and AD, we used a mediated Mendelian randomization method and screened for mediating variables between hypertension and AD by setting instrumental variables. The results of the mediated analysis showed that stroke, as a mediating variable, plays an important rol

SUBMITTER: Tang C 

PROVIDER: S-EPMC10703897 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature