Advancing peristalsis deciphering in mouse small intestine by multi-parameter tracking.

ABSTRACT: Assessing gastrointestinal motility lacks simultaneous evaluation of intraluminal pressure (ILP), circular muscle (CM) and longitudinal muscle (LM) contraction, and lumen emptying. In this study, a sophisticated machine was developed that synchronized real-time recordings to quantify the intricate interplay between CM and LM contractions, and their timings for volume changes using high-resolution cameras with machine learning capability, the ILP using pressure transducers and droplet discharge (DD) using droplet counters. Results revealed four distinct phases, B_Phase, N_Phase, D_Phase, and A_Phase, distinguished by pressure wave amplitudes. Fluid filling impacted LM strength and contraction frequency initially, followed by CM contraction affecting I

SUBMITTER: Sasidharan A 

PROVIDER: S-EPMC10703907 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature