Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC10703924 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
The thermosensitive transient receptor potential (TRP) channels are well-known as bio-thermometers with specific temperature thresholds and sensitivity. However, their precise structural origins are still mysterious. Here, graph theory was used to test how the temperature-dependent non-covalent interactions as identified in the 3D structures of thermo-gated TRPV3 could form a systematic fluidic grid-like mesh network with the constrained thermo-rings from the biggest grids to the smallest ones a ...[more]