Fascin-1 expression is associated with neuroendocrine prostate cancer and directly suppressed by androgen receptor.

ABSTRACT:

Background

Neuroendocrine prostate cancer (NEPC) is an aggressive form of prostate cancer, arising from resistance to androgen-deprivation therapies. However, the molecular mechanisms associated with NEPC development and invasiveness are still poorly understood. Here we investigated the expression and functional significance of Fascin-1 (FSCN1), a pro-metastasis actin-bundling protein associated with poor prognosis of several cancers, in neuroendocrine differentiation of prostate cancer.

Methods

Differential expression analyses using Genome Expression Omnibus (GEO) database, clinical samples and cell lines were performed. Androgen or antagonist's cellular treatments and knockdown experiments were used to detect changes in cell morphology, molecular markers, migration propert

SUBMITTER: Turpin A 

PROVIDER: S-EPMC10703930 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature