Downregulated NPAS4 in multiple brain regions is associated with major depressive disorder.

ABSTRACT: Major Depressive Disorder (MDD) is a commonly observed psychiatric disorder that affects more than 2% of the world population with a rising trend. However, disease-associated pathways and biomarkers are yet to be fully comprehended. In this study, we analyzed previously generated RNA-seq data across seven different brain regions from three distinct studies to identify differentially and co-expressed genes for patients with MDD. Differential gene expression (DGE) analysis revealed that NPAS4 is the only gene downregulated in three different brain regions. Furthermore, co-expressing gene modules responsible for glutamatergic signaling are negatively enriched in these regions. We used the results of both DGE and co-expression analyses to construct a novel MDD-associated pathway. In our model,

SUBMITTER: Selcuk B 

PROVIDER: S-EPMC10703936 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature