A spatiotemporal drug release scaffold with antibiosis and bone regeneration for osteomyelitis.

ABSTRACT:

Introduction

Scaffolds loaded with antibacterial agents and osteogenic drugs are considered essential tools for repairing bone defects caused by osteomyelitis. However, the simultaneous release of two drugs leads to premature osteogenesis and subsequent sequestrum formation in the pathological situation of unthorough antibiosis.

Objectives

In this study, a spatiotemporal drug-release polydopamine-functionalized mesoporous silicon nanoparticle (MSN) core/shell drug delivery system loaded with antibacterial silver (Ag) nanoparticles and osteogenic dexamethasone (Dex) was constructed and introduced into a poly-l-lactic acid (PLLA) scaffold for osteomyelitis therapy.

Methods

MSNs formed the inner core and were loaded with Dex through electrostatic adsorption (MSNs@Dex), a

SUBMITTER: Wu S 

PROVIDER: S-EPMC10704079 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature