Depth-sensitive diffuse speckle contrast topography for high-density mapping of cerebral blood flow in rodents.

ABSTRACT:

Significance

Frequent assessment of cerebral blood flow (CBF) is crucial for the diagnosis and management of cerebral vascular diseases. In contrast to large and expensive imaging modalities, such as nuclear medicine and magnetic resonance imaging, optical imaging techniques are portable and inexpensive tools for continuous measurements of cerebral hemodynamics. The recent development of an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) enables three-dimensional (3D) imaging of CBF distributions. However, scDCT requires complex and time-consuming 3D reconstruction, which limits its ability to achieve high spatial resolution without sacrificing temporal resolution and computational efficiency.

Aim

We investigate a new diffuse speckle contrast to

SUBMITTER: Mohtasebi M 

PROVIDER: S-EPMC10704187 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature