Skin capillary amylin deposition resembles brain amylin vasculopathy in rats.

ABSTRACT:

Background and purpose

Human amylin is a 37 amino-acid pancreatic peptide that forms neuro-toxic aggregates that deposit in the endothelium of brain capillaries of patients with diabetes, potentially contributing to cerebral small vessel ischemic injury. Pathogenic amylin also deposits in the capillary endothelium in other organs, including the skin. The aim of this study was to test the hypothesis that skin capillary amylin deposition correlates with cerebral small vessel amylin deposition, potentially providing a clinically useful marker of cerebral amylin deposition.

Methods

Immunohistochemistry (IHC) was performed for human amylin and collagen IV in brain and skin sections of rats (age 15-16 months) with pancreatic overexpression of amyloidogenic human amylin polypeptide

SUBMITTER: Das S 

PROVIDER: S-EPMC10704338 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature