Pregnancy After Breast Cancer in Young BRCA Carriers: An International Hospital-Based Cohort Study.

ABSTRACT:

Importance

Young women with breast cancer who have germline pathogenic variants in BRCA1 or BRCA2 face unique challenges regarding fertility. Previous studies demonstrating the feasibility and safety of pregnancy in breast cancer survivors included limited data regarding BRCA carriers.

Objective

To investigate cumulative incidence of pregnancy and disease-free survival in young women who are BRCA carriers.

Design, setting, and participants

International, multicenter, hospital-based, retrospective cohort study conducted at 78 participating centers worldwide. The study included female participants diagnosed with invasive breast cancer at age 40 years or younger between January 2000 and December 2020 carrying germline pathogenic variants in BRCA1 and/or BRCA2. Last deliv

SUBMITTER: Lambertini M 

PROVIDER: S-EPMC10704340 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature