Trends in Fracture Rates Over Two Decades Among Veterans With Ankylosing Spondylitis.

ABSTRACT:

Objective

There is an increased risk of fracture in individuals with ankylosing spondylitis (AS) compared to the general population, possibly due to systemic inflammatory effects. The use of tumor necrosis factor inhibitors (TNFi) may reduce fracture risk by inhibiting inflammation. We assessed fracture rates in AS versus non-AS comparators and whether these rates have changed since the introduction of TNFi.

Methods

We used the national Veterans Affairs database to identify adults ≥18 years old with ≥1 International Classification of Diseases, Ninth Revision (ICD-9)/ICD-10 code for AS and at least 1 disease-modifying antirheumatic drug prescription. As comparators, we selected a random sample of adults without AS diagnosis codes. We calculated fracture incidence rates for AS

SUBMITTER: Merjanah S 

PROVIDER: S-EPMC10704387 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature