Zwitterion modified cochlear implants resist postoperative infection and inflammation.

ABSTRACT: The cochlear implant (CI), an advanced electronic device replacing the entire cochlear function, is the ultimate treatment for over 466 million people with disabling hearing loss. Infection after cochlear implantation is a common and worrisome complication despite the routine administration of the antibiotic. The bacterial biofilms formed on the surface of CI are the main cause of antibiotic failure. To solve this problem, we developed a copper-containing zwitterionic coating consisting of anti-adherent poly sulfobetaine methacrylate (PSB) and steadfast polydopamine (PDA). CuSO₄/H₂O_2. was added to accelerate this co-deposition reaction and enhance the anti-bacterial property. The preparation method was simple, rapid, and suitable for clinical use. In our in

SUBMITTER: Chen A 

PROVIDER: S-EPMC10704433 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature