MIBlood-EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research.

ABSTRACT: Blood is the most commonly used body fluid for extracellular vesicle (EV) research. The composition of a blood sample and its derivatives (i.e., plasma and serum) are not only donor-dependent but also influenced by collection and preparation protocols. Since there are hundreds of pre-analytical protocols and over forty variables, the development of standard operating procedures for EV research is very challenging. To improve the reproducibility of blood EV research, the International Society for Extracellular Vesicles (ISEV) Blood EV Task Force proposes standardized reporting of (i) the applied blood collection and preparation protocol and (ii) the quality of the prepared plasma and serum samples. Gathering detailed information will provide insight into the performance of the protocols and

SUBMITTER: Lucien F 

PROVIDER: S-EPMC10704543 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature