Improved Screening of Monoclonal Gammopathy Patients by MALDI-TOF Mass Spectrometry.

ABSTRACT: Monoclonal gammopathies are a group of blood diseases characterized by presence of abnormal immunoglobulins in peripheral blood and/or urine of patients. Multiple myeloma and plasma cell leukemia are monoclonal gammopathies with unclear etiology, caused by malignant transformation of bone marrow plasma cells. Mass spectrometry with matrix-assisted laser desorption/ionization and time-of-flight detection is commonly used for investigation of the peptidome and small proteome of blood plasma with high accuracy, robustness, and cost-effectivity. In addition, mass spectrometry coupled with advanced statistics can be used for molecular profiling, classification, and diagnosis of liquid biopsies and tissue specimens in various malignancies. Despite the fact there have been fully optimized protoco

SUBMITTER: Pecinka L 

PROVIDER: S-EPMC10704583 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature