Disitamab Vedotin (RC48) for HER2-positive advanced breast cancer: a case report and literature review.

ABSTRACT:

Background/aim

Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is associated with a higher risk of metastasis and poorer overall survival (OS) due to HER2 gene overexpression/amplification. Although anti-HER2 targeted therapy has shown survival benefits in HER2-positive advanced breast cancer (ABC) patients, long-term treatment often leads to drug resistance, complicating further treatment options. RC48, an antibody-drug conjugate (ADC), combines the benefits of antibody targeting with the cytotoxic effects of a small molecule drug.

Case report

We present a case involving a female patient with HER2-positive ABC who developed drug resistance and disease progression following multi-line anti-HER2 targeted therapy. In this instance, RC48 exhibited anti-tu

SUBMITTER: Li Y 

PROVIDER: S-EPMC10704599 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature