Association of air pollution exposure and increased coronary artery disease risk: the modifying effect of genetic susceptibility.

ABSTRACT:

Background

Both genetic factors and air pollution are risk factors for coronary artery disease (CAD), but their combined effects on CAD are uncertain. The study aimed to comprehensively investigate their separate, combined and interaction effects on the onset of CAD.

Methods

We utilized data from the UK Biobank with a recruitment of 487,507 participants who were free of CAD at baseline from 2006 to 2010. We explored the separate, combined effect or interaction association among genetic factors, air pollution and CAD with the polygenic risk score (PRS) and Cox proportional hazard models.

Results

The hazard ratios (HRs) [95% confidence interval (CI)] of CAD for 10-µg/m³ increases in PM_2.5, NO₂ and NO_x concentrations were 1.25

SUBMITTER: Fu Z 

PROVIDER: S-EPMC10704645 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature