The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice.

ABSTRACT: Depression is two-to-three times more frequent among women. The hypothalamus, a sexually dimorphic area, has been implicated in the pathophysiology of depression. Neuroinflammation-induced hypothalamic dysfunction underlies behaviors associated with depression. The lipopolysaccharide (LPS)-induced mouse model of depression has been well-validated in numerous laboratories, including our own, and is widely used to investigate the relationship between neuroinflammation and depression. However, the sex-specific differences in metabolic alterations underlying depression-associated hypothalamic neuroinflammation remain unknown. Here, we employed the LPS-induced mouse model of depression to investigate hypothalamic metabolic changes in both male and female mice using a metabolomics approach. Thro

SUBMITTER: Xu FR 

PROVIDER: S-EPMC10704691 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature