Whole mitogenome sequencing uncovers a relation between mitochondrial heteroplasmy and leprosy severity.

ABSTRACT:

Background

In recent years, the mitochondria/immune system interaction has been proposed, so that variants of mitochondrial genome and levels of heteroplasmy might deregulate important metabolic processes in fighting infections, such as leprosy.

Methods

We sequenced the whole mitochondrial genome to investigate variants and heteroplasmy levels, considering patients with different clinical forms of leprosy and household contacts. After sequencing, a specific pipeline was used for preparation and bioinformatics analysis to select heteroplasmic variants.

Results

We found 116 variants in at least two of the subtypes of the case group (Borderline Tuberculoid, Borderline Lepromatous, Lepromatous), suggesting a possible clinical significance to these variants. Notably, 15 va

SUBMITTER: de Souza FG 

PROVIDER: S-EPMC10704783 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature