Changes in Treg and Breg cells in a healthy pediatric population.

ABSTRACT: The interpretation of clinical diagnostic results in suspected inborn errors of immunity, including Tregopathies, is hampered by the lack of age-stratified reference values for regulatory T cells (Treg) in the pediatric population and a consensus on which Treg immunophenotype to use. Regulatory B cells (Breg) are an important component of the regulatory system that have been poorly studied in the pediatric population. We analyzed (1) the correlation between the three immunophenotypic definitions of Treg (CD4⁺CD25^hiCD127^low, CD4⁺CD25^hiCD127^lowFoxP3⁺, CD4⁺CD25^hiFoxP3⁺), and with CD4⁺CD25^hi and (2) the changes in Treg and Breg frequencies and their maturation sta

SUBMITTER: Luo Y 

PROVIDER: S-EPMC10704817 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature