Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.

ABSTRACT: The SARS-CoV-2 pandemic not only resulted in millions of acute infections worldwide, but also in many cases of post-infectious syndromes, colloquially referred to as "long COVID". Due to the heterogeneous nature of symptoms and scarcity of available tissue samples, little is known about the underlying mechanisms. We present an in-depth analysis of skeletal muscle biopsies obtained from eleven patients suffering from enduring fatigue and post-exertional malaise after an infection with SARS-CoV-2. Compared to two independent historical control cohorts, patients with post-COVID exertion intolerance had fewer capillaries, thicker capillary basement membranes and increased numbers of CD169⁺ macrophages. SARS-CoV-2 RNA could not be detected in the muscle tissues. In addition, compleme

SUBMITTER: Aschman T 

PROVIDER: S-EPMC10704838 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature