Short-term effects of etifoxine on human gut microbiome in healthy men.

ABSTRACT:

Background

Neurosteroids have recently gained in interest as a treatment strategy for affective disorders. Etifoxine is known for its dual mode of action, one of which is to stimulate endogenous neurosteroid synthesis. The gut microbiome has been studied in affective disorders, but it has not been investigated in the context of human etifoxine or neurosteroid interventions.

Methods

We performed a crossover study with 36 healthy male volunteers who received etifoxine versus alprazolam and placebo in a balanced Williams design. Participants were randomized into six sequences and went through three 5-day treatments followed by wash-out phases of 9 days. Bacterial compositions in stool samples were determined by high-throughput 16S rRNA amplicon sequencing.

Results

Gut mi

SUBMITTER: Manook A 

PROVIDER: S-EPMC10704910 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature