Sex Chromosome Complement and Estradiol Modify Cocaine Self-Administration Behaviors in Male Mice.

ABSTRACT:

Introduction

Women are more vulnerable to cocaine's reinforcing effects and have a more rapid course to addiction after initial cocaine use as compared to men. Studies in rodents similarly indicate an enhanced sensitivity to the reinforcing effects of cocaine in females versus males. Levels of estradiol (E2) are correlated with vulnerability to the rewarding actions of cocaine. Here, we asked if sex chromosome complement (SCC) influences vulnerability to cocaine use.

Methods

We used the four-core genotype mouse that produces gonadal males and females with either XX or XY SCC. Mice were gonadectomized and implanted with either an estradiol (E2) or cholesterol-filled pellet. This allowed us to determine the effects of SCC in the absence (cholesterol-treated) and presence of to

SUBMITTER: Le AL 

PROVIDER: S-EPMC10704933 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature