MiR-196a Promotes Proliferation of Mammary Epithelial Cells by Targeting CDKN1B.

ABSTRACT: Heat stress (HS) has become one of the key challenges faced by the dairy industry due to global warming. Studies have reported that miR-196a may exert a role in the organism's response to HS, enhancing cell proliferation and mitigating cellular stress. However, its specific role in bovine mammary epithelial cells (BMECs) remains to be elucidated. In this study, we aimed to investigate whether miR-196a could protect BMECs against proliferation arrest induced by HS and explore its potential underlying mechanism. In this research, we developed an HS model for BMECs and observed a significant suppression of cell proliferation as well as a significant decrease in miR-196a expression when BMECs were exposed to HS. Importantly, when miR-196a was overexpressed, it alleviated the inhibitory effect

SUBMITTER: Chen G 

PROVIDER: S-EPMC10705059 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature