Extensive Alternative Splicing Patterns in Systemic Lupus Erythematosus Highlight Sexual Differences.

ABSTRACT: Substantial evidence highlights divergences in immune responses between men and women. Women are more susceptible to autoimmunity, whereas men suffer from the more severe presentation of autoimmune disorders. The molecular mechanism of this sexual dimorphism remains elusive. Herein, we conducted a comprehensive analysis of sex differences in whole-blood gene expression focusing on alternative splicing (AS) events in systemic lupus erythematosus (SLE), which is a prototype sex-biased disease. This study included 79 SLE patients with active disease and 58 matched healthy controls who underwent whole-blood RNA sequencing. Sex differences in splicing events were widespread, existent in both SLE and a healthy state. However, we observed distinct gene sets and molecular pathways targeted by sex-

SUBMITTER: Kosmara D 

PROVIDER: S-EPMC10705143 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature