Clonal Neoantigen: Emerging "Mechanism-based" Biomarker of Immunotherapy Response.

ABSTRACT: Clonal mutations represent the initiating molecular defects related to cellular transition of a normal phenotype to a malignant phenotype. Molecular genomic assessment utilizing next generation and whole exome sequencing is now being increasingly applied to biomarker determination to refine the use of targeted immune therapies. Case examples followed by retrospective study assessment have convincingly demonstrated clonal neoantigens provide a relevant predictor of response to checkpoint inhibition. A meta-analysis, by Litchfield et al., of over 1000 cancer patients from 12 landmark trials demonstrated no clinical benefit to checkpoint inhibitor (CPI) therapy in correlation to high subclonal tumor mutational burden (TMB), whereas high clonal TMB was found to be significantly correlated with

SUBMITTER: Nemunaitis J 

PROVIDER: S-EPMC10705148 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature