The Multifaceted Roles of Lamins in Lung Cancer and DNA Damage Response.

ABSTRACT: Emerging evidence suggests that lamin functions are not limited to maintaining the structural integrity of the nucleus in eukaryotic cells but that these functions affect many facets of cancer biology. An increasing number of reports suggest that adaptive changes in the lamin subtype composition within the nuclear lamina could affect essential features of cancer development and aggressiveness. These include regulation of cellular stiffness and mobility as well as epithelial-to-mesenchymal transition (EMT), all of which directly impact the metastatic properties of cancer cells. Additionally, insights from studies on the physiological functions of lamins suggest that cancer cells could hijack the ability of lamins to modify chromatin accessibility, cell cycle regulation, and DNA damage respo

SUBMITTER: Janetzko J 

PROVIDER: S-EPMC10705174 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature