T-cell receptor sequences correlate with and predict gene expression levels in T cells.
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ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC10705237 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Publications
T cell transcriptional landscapes are shaped by TCR sequence similarity.
bioRxiv : the preprint server for biology 20250412
T cells exhibit high heterogeneity in both their gene expression profiles and antigen specificities, but the precise relationship between these two features remains largely unknown. Utilizing a large-scale single-cell immune-profiling dataset that includes both T cell receptor (TCR) sequences and gene expression profiles of individual cells, we systematically investigated how the transcriptional profiles of T cells are linked to their TCR sequence similarity. We observed that T cells sharing the ...[more]
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