T-cell receptor sequences correlate with and predict gene expression levels in T cells.

ABSTRACT: T cells exhibit high heterogeneity in both their gene expression profiles and antigen specificities. We analyzed fifteen single-cell immune profiling datasets to systematically investigate the association between T-cell receptor (TCR) sequences and the gene expression profiles of T cells. Our findings reveal that T cells sharing identical or similar TCR sequences tend to have highly similar gene expression profiles. Additionally, we developed a foundational model that leverages TCR information to predict gene expression levels in T cells.

SUBMITTER: Wang H 

PROVIDER: S-EPMC10705237 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature