T-cell receptor sequences correlate with and predict gene expression levels in T cells.
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ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC10705237 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Publications
T-cell receptor sequences correlate with and predict gene expression levels in T cells.
bioRxiv : the preprint server for biology 20231128
T cells exhibit high heterogeneity in both their gene expression profiles and antigen specificities. We analyzed fifteen single-cell immune profiling datasets to systematically investigate the association between T-cell receptor (TCR) sequences and the gene expression profiles of T cells. Our findings reveal that T cells sharing identical or similar TCR sequences tend to have highly similar gene expression profiles. Additionally, we developed a foundational model that leverages TCR information t ...[more]
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