Cross-species and tissue imputation of species-level DNA methylation samples across mammalian species.

ABSTRACT: DNA methylation data offers valuable insights into various aspects of mammalian biology. The recent introduction and large-scale application of the mammalian methylation array has significantly expanded the availability of such data across conserved sites in many mammalian species. In our study, we consider 13,245 samples profiled on this array encompassing 348 species and 59 tissues from 746 species-tissue combinations. While having some coverage of many different species and tissue types, this data captures only 3.6% of potential species-tissue combinations. To address this gap, we developed CMImpute (Cross-species Methylation Imputation), a method based on a Conditional Variational Autoencoder, to impute DNA methylation for non-profiled species-tissue combinations. In cross-validation,

SUBMITTER: Maciejewski E 

PROVIDER: S-EPMC10705269 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature