Comparing Prognosis for BRCA1, BRCA2, and Non-BRCA Breast Cancer.

ABSTRACT: Germline pathogenic variants (PV) in BRCA1 and BRCA2 genes, which account for 20% of familial breast cancer (BC) cases, are highly penetrant and are associated with Hereditary Breast/Ovarian Cancer Syndrome. Previous studies, mostly including higher numbers of BRCA1 BC patients, yielded conflicting results regarding BRCA1/2 BC outcomes. In the Portuguese population, BRCA2 BC is diagnosed more frequently than BRCA1 BC. We aimed to compare clinicopathological characteristics and prognosis between BC patients with BRCA1 and BRCA2 mutations and a control group without germline PV (BRCA-wt). Furthermore, we explored the frequency and outcomes of risk-reducing surgeries in BRCA-mutated patients. Prospective follow-up was proposed for patients with a diagnosed BRCA1/2 PV. For this study, a matche

SUBMITTER: Antunes Meireles P 

PROVIDER: S-EPMC10705326 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature