Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is determined by T cells.

ABSTRACT: Following Mycobacterium tuberculosis infection, alveolar macrophages are initially infected but ineffectively restrict bacterial replication. The distribution of M. tuberculosis among different cell types in the lung changes with the onset of T cell immunity when the dominant infected cellular niche shifts from alveolar to monocyte-derived macrophages (MDM). We hypothesize that changes in bacterial distribution among different cell types is driven by differences in T cell recognition of infected cells and their subsequent activation of antimicrobial effector mechanisms. We show that CD4 and CD8 T cells efficiently eliminate M. tuberculosis infection in alveolar macrophages, but they have less impact on suppressing infection in MDM, which may be a bacterial niche. Impor

SUBMITTER: Lai R 

PROVIDER: S-EPMC10705395 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature