Connectomic reconstruction predicts the functional organization of visual inputs to the navigation center of the <i>Drosophila</i> brain.

ABSTRACT: Many animals, including humans, navigate their surroundings by visual input, yet we understand little about how visual information is transformed and integrated by the navigation system. In Drosophila melanogaster, compass neurons in the donut-shaped ellipsoid body of the central complex generate a sense of direction by integrating visual input from ring neurons, a part of the anterior visual pathway (AVP). Here, we densely reconstruct all neurons in the AVP using FlyWire, an AI-assisted tool for analyzing electron-microscopy data. The AVP comprises four neuropils, sequentially linked by three major classes of neurons: MeTu neurons, which connect the medulla in the optic lobe to the small unit of anterior optic tubercle (AOTUsu) in the central brain; TuBu neurons, which connect the

SUBMITTER: Garner D 

PROVIDER: S-EPMC10705420 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature