Efficient Radial-Shell Model for 3D Tumor Spheroid Dynamics with Radiotherapy.

ABSTRACT: Understanding the complex dynamics of tumor growth to develop more efficient therapeutic strategies is one of the most challenging problems in biomedicine. Three-dimensional (3D) tumor spheroids, reflecting avascular microregions within a tumor, are an advanced in vitro model system to assess the curative effect of combinatorial radio(chemo)therapy. Tumor spheroids exhibit particular crucial pathophysiological characteristics such as a radial oxygen gradient that critically affect the sensitivity of the malignant cell population to treatment. However, spheroid experiments remain laborious, and determining long-term radio(chemo)therapy outcomes is challenging. Mathematical models of spheroid dynamics have the potential to enhance the informative value of experimental data, and can support s

SUBMITTER: Franke F 

PROVIDER: S-EPMC10705470 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature