Effects of transient, persistent, and resurgent sodium currents on excitability and spike regularity in vestibular ganglion neurons.

ABSTRACT: Vestibular afferent neurons occur as two populations, regular and irregular, that provide distinct information about head motions. Differences in spike timing regularity are correlated with the different sensory responses important for vestibular processing. Relative to irregular afferents, regular afferents have more sustained firing patterns in response to depolarizing current steps, are more excitable, and have different complements of ion channels. Models of vestibular regularity and excitability emphasize the influence of increased expression of low-voltage-activated potassium currents in irregular neurons. We investigated the potential impact of different modes of voltage-gated sodium (Na_V) current (transient, persistent, and resurgent) in cell bodies from vestibular gangl

SUBMITTER: Baeza-Loya S 

PROVIDER: S-EPMC10705474 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature