Variant- and Vaccination-Specific Alternative Splicing Profiles in SARS-CoV-2 Infections.

ABSTRACT: The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, and its subsequent variants has underscored the importance of understanding the host-viral molecular interactions to devise effective therapeutic strategies. A significant aspect of these interactions is the role of alternative splicing in modulating host responses and viral replication mechanisms. Our study sought to delineate the patterns of alternative splicing of RNAs from immune cells across different SARS-CoV-2 variants and vaccination statuses, utilizing a robust dataset of 190 RNA-seq samples from our previous studies, encompassing an average of 212 million reads per sample. We identified a dynamic alteration in alternative splicing and genes related to RNA splicing were highly deactivated in COVID-19 patients and showed

SUBMITTER: Lee SG 

PROVIDER: S-EPMC10705549 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature