Functional haematopoietic progenitor cells in the adult human lung.

ABSTRACT: The bone marrow is classically viewed as the main site of blood cell production in adults, however, rare pools of haematopoietic stem and progenitor cells with self-renewal and differentiation potential have been described in extramedullary organs. The lung is primarily known for its role in gas exchange but has recently been identified as a site of blood (platelet) production in mice. Here, we show that functional haematopoietic precursors reside in the extravascular spaces of the human lung, at a frequency similar to the bone marrow, and are capable of proliferation and engraftment. Comparative transcriptomic profiling of pulmonary and medullary CD34⁺ haematopoietic progenitor cells revealed organ-specific gene signatures and indicated greater baseline activation of immune, me

SUBMITTER: Looney M 

PROVIDER: S-EPMC10705601 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature