Alzheimer's Related Neurodegeneration Mediates Air Pollution Effects on Medial Temporal Lobe Atrophy.

ABSTRACT: Exposure to ambient air pollution, especially particulate matter with aerodynamic diameter <2.5 μm (PM_2.5) and nitrogen dioxide (NO₂), are environmental risk factors for Alzheimer's disease and related dementia. The medial temporal lobe (MTL) is an important brain region subserving episodic memory that atrophies with age, during the Alzheimer's disease continuum, and is vulnerable to the effects of cerebrovascular disease. Despite the importance of air pollution it is unclear whether exposure leads to atrophy of the MTL and by what pathways. Here we conducted a longitudinal study examining associations between ambient air pollution exposure and MTL atrophy and whether putative air pollution exposure effects resembled Alzheimer's disease-related neurodegeneration or ce

SUBMITTER: Petkus AJ 

PROVIDER: S-EPMC10705654 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature