Diffuse Gliomas with FGFR3-TACC3 Fusions: Oncogenic Mechanisms, Hallmarks, and Therapeutic Perspectives.
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ABSTRACT:
SUBMITTER: Picca A
PROVIDER: S-EPMC10705668 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
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Diffuse Gliomas with FGFR3-TACC3 Fusions: Oncogenic Mechanisms, Hallmarks, and Therapeutic Perspectives.
Picca Alberto A Sansone Giulio G Santonocito Orazio Santo OS Mazzanti Chiara Maria CM Sanson Marc M Di Stefano Anna Luisa AL
Cancers 20231123 23
In 2012, whole-transcriptome sequencing analysis led to the discovery of recurrent fusions involving the <i>FGFR3</i> and <i>TACC3</i> genes as the main oncological driver in a subset of human glioblastomas. Since then, <i>FGFR3-TACC3</i> fusions have been identified in several other solid cancers. Further studies dissected the oncogenic mechanisms of the fusion protein and its complex interplay with cancer cell metabolism. <i>FGFR3-TACC3</i> fusion-driven gliomas emerged as a defined subgroup w ...[more]
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