Longitudinal latent polysubstance use patterns among a cohort of people who use opioids in Vancouver, Canada.

ABSTRACT:

Introduction

Polysubstance use (PSU) practices are increasing among people who use opioids (PWUO). However, several aspects of longitudinal PSU patterns among PWUO remain understudied. This study aims to identify person-centred longitudinal patterns of PSU among a cohort of PWUO.

Methods

Using longitudinal data (2005-2018) from three prospective cohort studies including people who use drugs in Vancouver, Canada, we used repeated measures latent class analysis to identify different PSU classes among PWUO. Multivariable generalised estimating equations models weighted by the respective posterior membership probabilities were applied to identify covariates of membership in different PSU classes over time.

Results

Overall, 2627 PWUO (median age at baseline: 36 [quartile 1

SUBMITTER: Karamouzian M 

PROVIDER: S-EPMC10705814 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature