CAR NK Cell Therapy for the Treatment of Metastatic Melanoma: Potential & Prospects.

ABSTRACT: Melanoma is among the most lethal forms of cancer, accounting for 80% of deaths despite comprising just 5% of skin cancer cases. Treatment options remain limited due to the genetic and epigenetic mechanisms associated with melanoma heterogeneity that underlie the rapid development of secondary drug resistance. For this reason, the development of novel treatments remains paramount to the improvement of patient outcomes. Although the advent of chimeric antigen receptor-expressing T (CAR-T) cell immunotherapies has led to many clinical successes for hematological malignancies, these treatments are limited in their utility by their immune-induced side effects and a high risk of systemic toxicities. CAR natural killer (CAR-NK) cell immunotherapies are a particularly promising alternative to CAR

SUBMITTER: Hibler W 

PROVIDER: S-EPMC10706172 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature